MediSense

From Natural Compounds to Patented Drug Assets

A computational drug discovery engine that transforms clinically validated natural product scaffolds into patent-protected drug candidates — targeting orphan diseases and companion animal health at a fraction of conventional cost and timeline.

Why Natural Compounds

Proven Starting Points

Most drug discovery starts from blank chemistry. We don't. Our starting compounds come from pharmacopoeias with decades to centuries of documented clinical use — with published pharmacokinetic data, known safety profiles, and real biological signals. This dramatically reduces translational risk.

Structure-Guided Engineering

The platform models how each molecule binds at residue-level resolution, then uses that structural feedback to guide molecular modifications — fluoroalkyl metabolic armor, aromatic ether binding enhancement, and calibrated ADMET prediction with literature-anchored domain shift correction.

Closed-Loop Validation

Every computational prediction is held accountable to wet-lab reality. Lead compounds are synthesized and validated through binding assays with international CROs. Each round of experimental data improves predictions across the entire compound matrix — a self-improving computational flywheel.

Platform Scale

Computational Engine
397
Protein targets across 5 therapeutic panels
1.31M
Docking pairs screened
225K
High-fidelity ML-rescored pairs
175
Production-grade targets (R² ≥ 0.7)
Pipeline & IP
195K+
Novel chemical entities generated
7+
US provisional patents filed
3
Lead compounds in pipeline
5
Therapeutic panels

Therapeutic Panels

Panel Targets Focus
CNS 256 Epilepsy, ALS, neurodegeneration, behavioral disorders
Human Safety 44 Standard 44-target off-target safety panel
Companion Animal Safety 28 Species-specific veterinary safety
Dermatology 50 Atopic dermatitis, immune-mediated skin conditions
Oncology 19 Drug-resistant hematologic malignancy (AML)

Pipeline

CNS / Companion Animal Lead Binding Assay In Progress

Multi-target compound designed for companion animal behavioral disorders. Synthesis complete via international CRO. Binding assay panel in progress. Results expected Q2 2026.

Oncology — AML Decision Gate

Dual-target candidate with computationally predicted activity against drug-resistant pathways. Awaiting lead program results before synthesis commitment.

Discovery Pipeline Active Optimization

Multiple candidates across rare pediatric epilepsy (DEE, Dravet Syndrome), ALS, translational dermatology, and additional orphan indications.

Intellectual Property

7+ US provisional patents protect our drug assets and the computational methods used to create them — including novel compound families, multi-target interaction prediction methodology, and indication-specific therapeutic claims across multiple independent scaffolds.

Partnership Opportunities

We offer patent-protected drug assets ready for licensing, co-development, or regional partnership — across orphan CNS, pediatric neurology, oncology, and companion animal health.

Pipeline assets available for licensing in both human orphan disease and companion animal health indications.